Dolasetron


w186



General information:


Withdrawn ID: w186
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): A04AA04
Molecular Formula: C19H20N2O3
Molweight: 324.38



Withdrawal information:


Withdrawn due to drug safety reasons:Yes
First approved: 1997
First withdrawn: 2011
Last withdrawn: 2011
Reference: https://www.ncbi.nlm.nih.gov/pubmed/3949982



Side-effects:

Total reported cases (submitted by medical professionals) with Dolasetron as primary suspect: 36


Reported final outcomes:
Hospitalization (initial or prolonged): 9
Death: 5
Life-Threatening condition: 4
Intervention required to prevent permanent impairment/damage: 1


Reported side-effects:

Side-effect Case number
BRADYCARDIA4
NAUSEA4
TREMOR3
LOSS OF CONSCIOUSNESS3
COMA3
ANAPHYLACTIC REACTION3
PAIN2
CARDIO-RESPIRATORY ARREST2
CARDIAC ARREST2
PRURITUS2
MEDICATION ERROR2
DYSKINESIA2
BLOOD PRESSURE DECREASED2
HYPOTENSION2
DYSPNOEA2
ANXIETY2
HEART RATE INCREASED2
TACHYCARDIA2
CONVULSION2
ONCOLOGIC COMPLICATION2
VOMITING2
DIZZINESS1
DRUG EXPOSURE DURING PREGNANCY1
DRUG DISPENSING ERROR1
FACIAL NEURALGIA1
DRUG INTERACTION1
DRUG PRESCRIBING ERROR1
DRUG TOXICITY1
DYSTONIA1
EJECTION FRACTION DECREASED1
ELECTROCARDIOGRAM ST SEGMENT DEPRESSION1
ENCEPHALOPATHY1
EXTRAPYRAMIDAL DISORDER1
ABDOMINAL DISCOMFORT1
BLOOD PRESSURE DIASTOLIC DECREASED1
ABDOMINAL PAIN1
ABDOMINAL PAIN UPPER1
ACCIDENTAL OVERDOSE1
ACUTE MYOCARDIAL INFARCTION1
ANAEMIA1
ANAESTHETIC COMPLICATION1
APNOEA1
ATRIOVENTRICULAR BLOCK1
BLOOD AMYLASE INCREASED1
DEVICE FAILURE1
BLOOD PRESSURE IMMEASURABLE1
BLOOD PRESSURE INCREASED1
BODY TEMPERATURE INCREASED1
CAESAREAN SECTION1
CARDIAC FAILURE1
CERVICAL INCOMPETENCE1
COMPARTMENT SYNDROME1
DEPRESSED LEVEL OF CONSCIOUSNESS1
SKIN REACTION1
PREMATURE LABOUR1
PULMONARY EMBOLISM1
PULMONARY OEDEMA1
RESPIRATORY RATE INCREASED1
SEDATION1
SENSORY DISTURBANCE1
SENSORY LOSS1
SEROTONIN SYNDROME1
SHOCK1
SKIN LACERATION1
PHARYNGITIS1
SPEECH DISORDER1
SUICIDAL IDEATION1
SUPRAVENTRICULAR TACHYCARDIA1
SWELLING FACE1
TENDON INJURY1
THROMBOCYTOPENIA1
TROPONIN I INCREASED1
URTICARIA GENERALISED1
VISION BLURRED1
MYOCARDIAL INFARCTION1
FEELING ABNORMAL1
GRIP STRENGTH DECREASED1
HAEMATEMESIS1
HEART RATE DECREASED1
HYPERHIDROSIS1
HYPOKINESIA1
HYPOVOLAEMIA1
INFLAMMATION1
INTERCEPTED MEDICATION ERROR1
MOVEMENT DISORDER1
FALL1
NEUTROPENIA1
NIGHTMARE1
OCULOGYRATION1
OPISTHOTONUS1
OSTEONECROSIS1
OXYGEN SATURATION DECREASED1
PANCREATITIS1
PARAESTHESIA1
PETECHIAE1





Filtered ChEMBL targets:

Target UniProtKB ID Activity in nm Target Name Target gene
Q12809 5950 Potassium voltage-gated channel subfamily H member 2 KCNH2_HUMAN



Toxicity information:

Toxicity class: 4
Toxicity type: cardiovascular
LD50: 405 mg/kg



External links:

ChEBML: CHEMBL2368925
DrugBank: DB00757